Mitochondria-targeted Cardioprotection in Aldosteronism
نویسندگان
چکیده
منابع مشابه
Cardioprotection: nitric oxide, protein kinases, and mitochondria.
Over the past 2 to 3 decades, several phenomena have been identified that provide powerful protection against myocardial infarction and other sequelae of ischemia/reperfusion1: myocardial hibernation that is related to stunning,2 ischemic preconditioning,3 delayed or second-window ischemic preconditioning,4 ischemic postconditioning,5 and their pharmacological recruitment. Stunning and hibernat...
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Superoxide ( [Formula: see text] ) has been implicated in the pathogenesis of many human diseases including hypertension. Mitochondria-targeted superoxide scavenger mitoTEMPO reduces blood pressure; however, the structure-functional relationships in antihypertensive effect of mitochondria-targeted nitroxides remain unclear. The nitroxides are known to undergo bioreduction into hydroxylamine der...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Pharmacology
سال: 2011
ISSN: 0160-2446
DOI: 10.1097/fjc.0b013e3181fe1250